Wet Cupping Therapy causes increased capillary filtration, local collection of filtered fluids, lymph, and interstitial fluids, and their retention inside the lifted skin. This dilutes chemical substances, inflammatory mediators (is a messenger that acts on blood vessels and/or cells to promote an inflammatory response ), and nociceptive substances, bathes nerve endings in collected fluids, and breaks tissue adhesions, resulting in decreased pain 
- El Sayed S, Mahmoud H, Nabo M. Methods of wet cupping therapy (Al-Hijamah): in light of modern medicine and prophetic medicine. Altern Integ Med. 2013;2(3):1–16.